LDN-193189

Product Name: LDN-193189
CAS No.: 1062368-24-4
Chemical Name: LDN-193189
Synonyms: LDN193189;CS-205;DM-3189;DM 3189;LDN193189(DM3189);LDN-193189, >=98%;LDN193189 free base;LDN-193189;LDN 193189;LDN193189 LDN193189 HCl;LDN-193189;LDN 193189;DM-3189;DM 3189
CBNumber: CB22512071
Molecular Formula: C25H22N6
Formula Weight: 406.48
MOL File: 1062368-24-4.mol

More

Less

LDN-193189 Property

Density: 1.33
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: H2O: soluble5mg/mL, clear (warmed)
form: powder
pka: 8.79±0.10(Predicted)
color: yellow to orange
InChIKey: XHBVYDAKJHETMP-UHFFFAOYSA-N

More

Less

Safety

WGK Germany: 3
HS Code: 29339900

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0559
Product name: LDN193189 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $130
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0559
Product name: LDN193189 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $522
Updated: 2024/03/01

Cayman Chemical

Product number: 11802
Product name: LDN-193189
Purity: ≥95%
Packaging: 1mg
Price: $35
Updated: 2024/03/01

Cayman Chemical

Product number: 11802
Product name: LDN-193189
Purity: ≥95%
Packaging: 5mg
Price: $96
Updated: 2024/03/01

Cayman Chemical

Product number: 11802
Product name: LDN-193189
Purity: ≥95%
Packaging: 10mg
Price: $140
Updated: 2024/03/01

More

Less

LDN-193189 Chemical Properties,Usage,Production

Description

Normal development and tissue repair are controlled in part by SMADs, a family of intracellular proteins that are activated by signaling via serine/threonine kinase receptors of the TGF-β superfamily. LDN-193189 inhibits SMAD1/5/8 phosphorylation by the bone morphogenetic protein (BMP) type I receptors, which are known as activin receptor-like kinases (ALKs), with an IC₅₀ value of 4.9 nM. In in vitro kinase assays, it shows specificity for ALK1, 2, 3, and 6 (IC₅₀s = 0.8, 0.8, 5.3, and 16.7 nM, respectively) over ALK4 and 5 (IC₅₀s = 101 and 350 nM, respectively). LDN-193189 has been used to inhibit BMP type I receptor activity to study the pathogenesis of fibrodysplasia ossificans progressive, a congenital hyperossification disorder, and to examine the role of osteogenesis in prostate tumor metastases in bone.

Uses

4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline, is a selective inhibitor of bone morphogenetic protein (BMP) pathway, useful in the treatment of diseases. Potent BMP Inhibitor?, Promotes hPSC Neural Induction?.

Definition

ChEBI: 4-[6-[4-(1-piperazinyl)phenyl]-3-pyrazolo[1,5-a]pyrimidinyl]quinoline is a member of pyrimidines.

Biochem/physiol Actions

Although LDN193189 is a structural analog of dorsomorphin, these two drugs are found to establish different cellular responses. In vitro analysis reveals that LDN193189 inhibits a number of intracellular kinases such as, mitogen activated protein kinase 14 and 8 ( p38and c-Jun N-terminal kinase respectively), as well as those associated with AKT (serine/threonine kinase) and mTOR (mammalian target of rapamycin) signaling mechanisms. LDN193189 is known to elevate the levels hemoglobin and thus helps to prevent the onset of anemia of inflammation.

References

[1] yu pb, deng dy, lai cs, hong cc, cuny gd, bouxsein ml, hong dw, mcmanus pm, katagiri t, sachidanandan c, kamiya n, fukuda t, mishina y, peterson rt, bloch kd. bmp type i receptor inhibition reduces heterotopic [corrected] ossification. nat med. 2008 dec;14(12):1363-9.
[2] boergermann jh1, kopf j, yu pb, knaus p. dorsomorphin and ldn-193189 inhibit bmp-mediated smad, p38 and akt signalling in c2c12 cells. int j biochem cell biol. 2010 nov;42(11):1802-7.
[3] helbing t1, herold em, hornstein a, wintrich s, heinke j, grundmann s, patterson c, bode c, moser m. inhibition of bmp activity protects epithelial barrier function in lung injury. j pathol. 2013 sep;231(1):105-16. doi: 10.1002/path.4215. epub 2013 jul 10.

LDN-193189 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

LDN-193189 Suppliers

China 134 India 2 United States 20 Global 156

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2784
Advantage: 58

Target molecule Corp.

Tel: 857-239-0968
Fax: 857-239-8801
Email: service1@targetmol.com
Country: United States
ProdList: 2559
Advantage: 60

Musechem

Tel: +1-800-259-7612
Fax: +1-800-259-7612
Email: info@musechem.com
Country: United States
ProdList: 4662
Advantage: 60

Alfa Chemistry

Tel: +1-5166625404
Fax: 1-516-927-0118
Email: Info@alfa-chemistry.com
Country: United States
ProdList: 21317
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 19892
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6393
Advantage: 58

Cckinase, Inc.

Tel: +1 (732)236-3202
Email: sales@cckinase.com
Country: United States
ProdList: 2738
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19553
Advantage: 58

Aladdin Scientific

Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Country: United States
ProdList: 57511
Advantage: 58

More

Less

View Lastest Price from LDN-193189 manufacturers

Career Henan Chemical Co

Product: 6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine 1062368-24-4
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-08

1062368-24-4, LDN-193189Related Search:

LDN-212320 LDN-193189 HCl 2,5-Dimethoxyaniline tert-Butyl 1-piperazinecarboxylate Piperazine LDN-214117 Y27632 (hydrochloride) 1,9-Pyrazoloanthrone SB 431542 LY2109761 ICG-001 LDN212854 Ldn193189

LDN193189 LDN193189 HCl

4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline

LDN-193189;LDN 193189;DM-3189;DM 3189

LDN-193189;LDN 193189

CS-205

LDN193189 free base

LDN193189(DM3189)

LDN193189

4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline

DM 3189

DM-3189

6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyriMidine LDN 193189(DM3189)

4-{6-[4-(piperazin-1-yl)phenyl]pyrazolo[

4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline LDN 193189

LDN 193189 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline

4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-quinoline hydrochloride

LDN-193189, >=98%

LDN-193189, 98%, a selective BMP signaling inhibitor

Quinoline, 4-[6-[4-(1-piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]-

6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidine USP/EP/BP

1062368-24-4

C25H22N6

Smad

TGF-beta

Inhibitors

TGF-beta/Smad